Will, a lackluster college student, returns to his dorm after spring break to find his younger brother, Cory, visiting him for the week. After ditching classes and his brother, Will returns to the dorm to find it overrun... with zombies! While escaping from the zombie infested dorm with his younger brother dragging behind him, Will becomes the unsuspecting leader of a group of quirky survivors: an emo chick, geek know-it-all, poli-sci chain smoker, over-achieving tomboy, and manipulative journalist.

On their journey to the student television station in an attempt to broadcast for help, the group of misfits encounters all the elements of the college experience. Complete with zombie keggers and bookworms to football games and lecture halls, Will must learn to lead his new friends to safety in the midst of tragedy and loss while reconciling his relationship with Cory.